C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/422 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2526995
The invention relates to the bicyclic heterocycles of general formula (I), wherein Ra, Rb, Rc, Rd, X and n are defined as in claim 1, to their tautomers, stereoisomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids. The inventive compounds have valuable pharmacological properties, especially they inhibit tyrosinkinase-mediated signal transduction. The invention also relates to the use of said compounds for treating diseases, especially tumor diseases and benign prostatic hyperplasia (BPH), diseases of the lung and respiratory tracts, and to the production of these compounds.
L'invention concerne des hétérocycles bicycliques de formule générale (I), dans laquelle R?a¿, R?b¿, R?c¿, R?d¿, X et n ont la signification indiquée dans la revendication 1, leurs tautomères, leurs stéréoisomères, leurs mélanges et leurs sels, notamment leurs sels physiologiquement tolérables comportant des acides inorganiques et organiques, qui présentent des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur la transduction de signaux médiée par les tyrosine kinases. Elle concerne également leur utilisation pour le traitement de maladies, notamment de maladies tumorales et de l'hyperplasie bénigne de la prostate (BPH), de maladies pulmonaires et de maladies des voies respiratoires, ainsi que la production desdits composés.
Himmelsbach Frank
Jung Birgit
Soyka Rainer
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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