Bicyclic heterocycles, pharmaceutical compositions...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/14 (2006.01) A61K 31/553 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2516426

The invention relates to bicyclic heterocycles of general formula (I), wherein Ra, Rb, Rc, Rd, Re, and X have the definitions indicated in claim 1, the tautomers, stereoisomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof containing inorganic or organic acids having valuable pharmaceutical properties, especially an inhibiting effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, especially cancer diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and the production thereof.

L'invention concerne des hétérocycles bicycliques de formule générale (I), leurs tautomères, stéréoisomères, mélanges et sels, en particulier leurs sels physiologiquement acceptables qui comportent des acides inorganiques ou organiques. Dans ladite formule (I), R?a¿, R?b¿, R?c¿, R?d¿, R?e¿ et X sont tels que définis dans la première revendication. Lesdits composés présentent des propriétés pharmacologiques précieuses et ont notamment pour effet d'empêcher la transduction de signaux dont la médiation est assurée par des tyrosine kinases. La présente invention se rapporte en outre à l'utilisation de ces composés pour traiter des maladies, en particulier des maladies tumorales ainsi que l'hyperplasie prostatique bénigne (BPH) et des maladies pulmonaires et des voies aériennes, ainsi qu'à la production desdits composés.

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