C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/675 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 471/04 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2361770
The present invention relates to bicyclic heterocyclic compounds of general formula (I) wherein Ra, Rb, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosinekinases, their use in treating diseases, particularly tumour diseases, diseases of the lung and airways and the preparation thereof.
La présente invention concerne des composés hétérocycliques bicycliques de formule (I) dans laquelle R¿a?, R¿b?, X et Y sont tels que définis dans la revendication 1, ainsi que leurs tautomères, leurs stéréoisomères et leurs sels, plus particulièrement les sels physiologiquement acceptables de ces derniers associés à des acides ou des bases organiques ou inorganiques qui possèdent des propriétés pharmacologiques intéressantes, plus spécifiquement un effet inhibiteur sur la transduction du signal assistée par des tyrosine kinases, leur utilisation dans le traitement des maladies et plus particulièrement des maladies tumorales, des maladies pulmonaires et des voies aériennes ainsi que la préparation de ces composés.
Blech Stefan
Himmelsbach Frank
Jung Birgit
Langkopf Elke
Metz Thomas
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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