C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/08 (2006.01) A61K 31/5386 (2006.01)
Patent
CA 2484395
The present invention relates to bicyclic heterocycles of general formula (see formula I) wherein R a is H or alkyl; R b is optionally substituted phenyl, benzyl or phenethyl; R c is H, halo, -OH, optionally substituted alkoxy, etc.; A is imino or alkylimino; B is carbonyl or sulphonyl; C' is optionally substituted alkenylene; D is alkylene; E is an optionally substituted heterocylic group wherein two hydrogen atoms or carbon atoms of the cyclic skeleton are replaced with an alkylene bridge; and X is substituted methyne, the tautomers, the stereoisomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and the preparation thereof.
La présente invention concerne des hétérocycles bicycliques de la formule générale (I), où R?a¿, R?b¿, R?c¿, A, B, C, D, E et X ont la définition donnée dans la revendication 1, leurs tautomères, leurs stéréo-isomères, leurs mélanges et leurs sels, notamment leurs sels physiologiquement compatibles avec des acides inorganiques ou organiques ayant de précieuses caractéristiques pharmacologiques, notamment une action inhibitrice sur la transduction de signaux transmise par la tyrosine-kinase. L'invention concerne également leur utilisation pour le traitement de maladies, notamment de maladies tumorales et de l'hypertrophie de la prostate (BPH), de maladies des poumons et des voies respiratoires, ainsi que leur production.
Himmelsbach Frank
Jung Birgit
Solca Flavio
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
LandOfFree
Bicyclic heterocycles, pharmaceutical compositions... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bicyclic heterocycles, pharmaceutical compositions..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic heterocycles, pharmaceutical compositions... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1771881