C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 239/94 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2375259
The present invention relates to bicyclic heterocycles of general formula (see formula I) wherein R a to R c, A to E and X are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologi- cally acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and air-ways, and the preparation thereof.
L'invention concerne des hétérocycles bicycliques de la formule générale (I) dans laquelle Ra à Rc, A à E et X ont la signification mentionnée dans la revendication 1. L'invention concerne en outre leurs tautomères, leurs stéréoisomères et leurs sels, notamment leurs sels physiologiquement tolérables présentant des acides organiques ou inorganiques ou des bases, qui présentent des propriétés pharmacologiques précieuses, en particulier un effet inhibiteur sur la transduction de signaux induite par tyrosine kinases. L'invention concerne par ailleurs l'utilisation desdits composés pour traiter des affections, notamment des pathologies tumorales, des affections du poumon et des voies respiratoires et leur préparation.
Baum Anke
Himmelsbach Frank
Jung Birgit
Langkopf Elke
Metz Thomas
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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