Bicyclic heterocyclic compounds

Details Bicyclic heterocyclic compounds Bicyclic heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 265/36 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 265/18 (2006.01) C07D 279/16 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2044219

Z/PH 3579 A B S T R A C T BICYCLIC HETEROCYCLIC COMPOUNDS The invention concerns a bicyclic heterocyclic compound of the formula I Image I wherein Q is an optionally substituted 10-membered bicyclic heterocyclic moiety containing 1 or 2 N's and a further O or S heteroatom; A1 is a direct link to X1 or (1-3C)alkylene; X1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar is optionally substituted phenylene or pyridylene; R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R2 and R3 together form a group of the formula -A2-X2-A3- which, together with the carbon atom to which A2 and A3 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A2 and A3 is (1-3C)alkylene and X2 is oxy, thio, sulphinyl or sulphonyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme S-lipoxygenase.

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