Bicyclic heterocyclic derivatives and their use as...

Details Bicyclic heterocyclic derivatives and their use as... Bicyclic heterocyclic derivatives and their use as...

A - Human Necessities

61

K

A61K 31/4184 (2006.01) A61K 31/5025 (2006.01) A61P 3/04 (2006.01) C07D 235/08 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2580781

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

L'invention concerne des procédés de traitement de maladie ou d'affection à médiation assurée par stéaroyl-CoA désaturases (SCD) chez un mammifère, de préférence un humain : par exemple, administration au mammifère d'un composé de formule (I), dans laquelle x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 et R8a sont tels que définis aux fins de la description. On décrit aussi des compositions pharmaceutiques comprenant les composés en question.

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