Bicyclic heterocyclic p-38 kinase inhibitors

Details Bicyclic heterocyclic p-38 kinase inhibitors Bicyclic heterocyclic p-38 kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2548326

Provided are bicyclic heterocycle-based p38 kinase, including p38.alpha. and p38.beta. kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amehoration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

La présente invention se rapporte à des inhibiteurs hétérocycliques bicycliques des kinases p38, notamment des kinases p38.alpha. et p38.beta.. L'invention concerne aussi des compositions pharmaceutiques contenant lesdits composés. L'invention a également trait à des procédés d'utilisation des composés et des compositions selon l'invention, notamment à des méthodes permettant de traiter, de prévenir ou d'atténuer un ou plusieurs symptômes de maladies et troubles induits par les kinases p38, notamment, mais de façon non limitative, des maladies et des troubles inflammatoires.

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