Bicyclic heterocyclic spiro compounds

Details Bicyclic heterocyclic spiro compounds Bicyclic heterocyclic spiro compounds

C - Chemistry, Metallurgy

07

D

C07D 491/10 (2006.01) A61K 31/424 (2006.01) A61K 31/429 (2006.01) A61K 31/438 (2006.01) C07D 491/20 (2006.01) C07D 495/10 (2006.01) C07D 498/10 (2006.01) C07D 513/10 (2006.01)

Patent

CA 2750777

There are disclosed bicyclic heterocyclic spiro compounds; pharmaceutical compositions comprising these compounds; and methods for the treatment in a mammal of diseases and conditions which are susceptible to modulation of the M1 muscarinic receptor, including Alzheimer's disease, insulin resistance syndrome and type 2 diabetes. Other embodiments are also disclosed.

L'invention porte sur des composés spiro hétérocycliques bicycliques, sur des compositions pharmaceutiques comprenant ces composés; et sur des procédés pour le traitement chez un mammifère de maladies et d'états qui sont sensibles à une modulation du récepteur muscarinique M1, comprenant la maladie d'Alzheimer, le syndrome de résistance à l'insuline et le diabète de type 2. D'autres modes de réalisation sont également décrits.

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