Bicyclic inhibitors of factor xa

Details Bicyclic inhibitors of factor xa Bicyclic inhibitors of factor xa

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/542 (2006.01) A61K 31/548 (2006.01) A61K 38/55 (2006.01) A61P 7/02 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2447488

This invention relates generally to a novel class of bicyclic heterocyclic compounds of the Formula (I), or pharmaceutically acceptable salt forms thereof, which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.

l'invention concerne généralement une classe de composés hétéro-bicycliques de formule (I), ou des formes salines de ces composés acceptables sur le plan pharmaceutique, qui sont des inhibiteurs d'enzymes protéases à sérine de type trypsine, plus spécialement du facteur Xa, des compositions pharmaceutiques contenant ces compositions, ainsi que des méthodes d'utilisation des ces composés comme anticoagulants destinés au traitement et à la prévention de troubles thromboemboliques.

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