Bicyclic inhibitors of mek and methods of use thereof

Details Bicyclic inhibitors of mek and methods of use thereof Bicyclic inhibitors of mek and methods of use thereof

A - Human Necessities

01

N

A01N 43/64 (2006.01) A01N 33/02 (2006.01) A01N 43/42 (2006.01) A01N 43/54 (2006.01) A01N 43/58 (2006.01) A01N 43/60 (2006.01) A01N 43/90 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2546353

Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

L'invention concerne des composés de formule (I), ainsi que des sels pharmaceutiquement acceptables et des promédicaments de ces composés. Dans ladite formule (I), R?1¿, R?2¿, R?8¿, R?9¿ et R?10¿, W, X, et Z sont tels que définis dans la description. Ces composés sont des inhibiteurs de MEK et peuvent être utilisés pour traiter des maladies impliquant une hyperprolifération, telles que cancers et inflammations, chez des mammifères, ainsi que des états inflammatoires. Cette invention se rapporte en outre à des procédés d'utilisation de ces composés pour traiter des maladies impliquant une hyperprolifération, chez des mammifères, ainsi qu'à des compositions pharmaceutiques renfermant lesdits composés.

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