Bicyclic kinase inhibitors

Details Bicyclic kinase inhibitors Bicyclic kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/47 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2735779

New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase- mediated disorder, such as cancer.

Linvention concerne de nouveaux composés, compositions et procédés destinés à inhiber lactivité de la kinase dintégration provirale de Maloney (kinase PIM) associée à une tumorigenèse chez un sujet humain ou animal. Dans certains modes de réalisation, les composés et compositions sont efficaces pour inhiber lactivité dau moins une kinase PIM. Les nouveaux composés et compositions peuvent être utilisés soit seuls soit en combinaison avec au moins un agent supplémentaire pour le traitement dun trouble à médiation par la sérine/thréonine kinase ou par le récepteur tyrosine kinase, tel que le cancer.

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