C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01) C07F 9/6561 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2192360
Disclosed are compounds, compositions, and methods for inhibiting interleukin-1.beta. protease activity, having formala (A), wherein Y = (a) or (b) or (c), Z = various bicyclic lactams with a bridgehead nitrogen.
L'invention concerne des composés, des compositions et des procédés d'inhibition de l'activité de protéase de l'interleukine-1 beta . Dans la formule (A), Y désigne le groupe (a), (b) ou (c) et Z désigne des lactames bicycliques divers ayant un pont d'azote.
Chaturvedula Prasad V.
Dolle Roland E.
Morgan-Ross Tina
Schmidt Stanley J.
Fetherstonhaugh & Co.
Sanofi Winthrop Inc.
Vertex Pharmaceuticals Incorporated
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