Bicyclic nitrogen-containing heterocyclic compounds for use...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 241/44 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2665476

The present invention discloses bicyclic nitrogen-containing heterocyclic compounds for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, oily skin conditions, metabolic syndrome, and the like.

La présente invention concerne des composés hétérocycliques azotés bicycliques pour une utilisation en tant qu'inhibiteurs de stéaroyl-CoA-désaturase. Les composés sont utiles dans le traitement et/ou la prévention de diverses maladies humaines, ayant pour origine les enzymes stéaroyl-CoA-désaturase (SCD), plus particulièrement les maladies liées à des niveaux de lipides anormaux, une maladie cardiovasculaire, les diabètes, l'obésité, l'aspect graisseux de la peau, un syndrome métabolique et analogues.

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