C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/44 (2006.01) A61K 31/498 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2719650
The present invention discloses bicyclic nitrogen-containing heterocyclic compounds for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, oily skin conditions, metabolic syndrome, and the like.
La présente invention concerne des composés hétérocycliques bicycliques contenant de lazote pour une utilisation en tant quinhibiteurs de la stéaroyl-CoA désaturase. Les composés sont utiles pour le traitement et/ou la prévention de diverses maladies humaines, médiées par les enzymes stéaroyl-CoA désaturase (SCD), notamment de maladies associées à des niveaux lipidiques anormaux, de maladies cardiovasculaires, du diabète, de lobésité, de la peau grasse, du syndrome métabolique et analogues.
Chisholm Jeffrey
Glushkov Andrei
Ivanov Alexey
Koltun Dmitry
Parkhill Eric
Gilead Sciences Inc.
Robic
LandOfFree
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