Bicyclic oxazine and thiazine oxazolidinone antibacterials

Details Bicyclic oxazine and thiazine oxazolidinone antibacterials Bicyclic oxazine and thiazine oxazolidinone antibacterials

C - Chemistry, Metallurgy

07

D

C07D 491/08 (2006.01) A61K 31/42 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 495/08 (2006.01)

Patent

CA 2201736

Phenyloxazolidinone compounds of formula (I) or a pharmaceutically acceptable salt thereof characterized by a bicyclic thiazine or oxazine substituent. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

L'invention concerne des composés phényloxazolidinone de la formule (I) ou les sels de ceux-ci acceptables sur le plan pharmaceutique, caractérisés par la présence d'un substituant oxazine ou thiazine bicyclique. Ces composés sont utiles comme agents antimicrobiens, et sont efficaces contre de nombreux agents pathogènes de l'homme et d'animaux, en particulier contre des bactéries aérobies Gram positives telles que les staphylocoques, les streptocoques et les entérocoques ayant développé une résistance multidrogue, ainsi que contre des organismes anaérobies tels que Bactéroides spp. et Clostridia spp. et des organismes acido-résistants tels que Mycobactérium tuberculosis, Mycobactérium avium et Mycobactérium ssp.

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