Bicyclic piperidine derivatives as antagonists of the ccr1...

Details Bicyclic piperidine derivatives as antagonists of the ccr1... Bicyclic piperidine derivatives as antagonists of the ccr1...

C - Chemistry, Metallurgy

07

D

C07D 451/06 (2006.01) A61K 31/46 (2006.01) A61K 31/538 (2006.01) A61K 31/55 (2006.01) A61P 37/02 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01)

Patent

CA 2492110

A compound of the formula (I) wherein a, b, cR1, R2, R3, R4, R5, R6, Q, W, Y, and Z are defined as above, useful as potent and selective inhibitors of MIP- 1.alpha.(CCL3) binding to its receptor CCR1 found on inflammatory and immunomodulatory cells (preferably leukocytes and lymphocytes).

L'invention concerne un composé représenté par la formule (I) dans laquelle a, b, c, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, Q, W, Y, et Z sont tels que définis dans le descriptif. Ce composé est indiqué en tant qu'inhibiteur puissant et sélectif de la liaison de MIP-1.alpha.(CCL3) avec son récepteur CCR1 présent sur les cellules inflammatoires et immunomodulatrices (de préférence leucocytes et lymphocytes).

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