Bicyclic prostaglandins and process for their preparation

C - Chemistry – Metallurgy – 07 – D

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260/235.01

C07D 307/935 (2006.01) C07D 311/94 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1183839

Abstract of the Disclosure This invention relates to a compound of formula (I) (I) Image wherein R is a member selected from the group consisting of (a) a free or esterified carboxy group; (b) Image , wherein each of the R' groups, which are the same or different, is C1-C6 alkyl or phenyl; (c) -CH2OH; (d) Image wherein Ra and Rb are independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkanoyl and phenyl; (e) a radical Image ; (f) Image ; Z1 is hydrogen or halogen; p is zero or an integer of 1 to 7; q is 1 or 2; R1 is hydrogen3 hydroxy, C1-C6 alkoxy, ar-C1-C6-alkoxy, acyloxy; Y is a member selected from the group consisting of -CH2CH2-, Image , Image (cis) and Image (trans), wherein Z2 is hydrogen or halogen;

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