Bicyclic pyrazolidine, pyridazine and diazepine derivatives

Details Bicyclic pyrazolidine, pyridazine and diazepine derivatives Bicyclic pyrazolidine, pyridazine and diazepine derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/299

C07D 487/04 (2006.01) C07D 209/48 (2006.01) C07D 231/04 (2006.01) C07D 237/04 (2006.01) C07D 403/06 (2006.01) C07F 9/38 (2006.01) C07F 9/40 (2006.01) C07F 9/6509 (2006.01) C07F 9/6561 (2006.01) C07K 5/078 (2006.01)

Patent

CA 1234568

RAN 4019/91 ABSTRACT Novel compounds of the formula Image I wherein B represents a methylene, ethylene or vinylene group, R1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono- -alkylamino-alkyl, dialkylamino- -alkyl, acylamino-alkyl, phthali- mido-alkyl, alkoxycarbonylamino- -alkyl, aryloxycarbonylamino-alkyl, aralkoxycarbonylamino-alkyl, alkyl- aminocarbonylamino-alkyl, arylamino- carbonylamino-alkyl, aralkylamino- carbonylamino-alkyl, alkylsulphonyl- amine-alkyl or arylsulphonylamino- -alkyl group, R2 represents a car- boxyl, alkoxycarbonyl or aralkoxy- carbonyl group or a group of the formula Image (i) or (ii) , R3 represents a carboxyl, alkoxy- carbonyl or aralkoxycarbonyl group, R4 and R5 each represent a hydrogen atom or R4 and R5 together represent an oxo group, R6 and R each re- present a hydrogen atom or an alkyl or aralkyl group or R6 and R7 to- gether with the nitrogen atom to which they are attached represent a 5-membered or 6-membered hetero- monocyclic ring which may contain a further nitrogen atom or an oxygen or sulphur atom, and n stands for zero, 1 or 2, and pharmaceutically acceptable salts thereof have anti- hypertensive activity and can be used as medicaments in the form of pharmaceutical preparations.

427095

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