C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61P 17/04 (2006.01) A61P 29/00 (2006.01) C07D 403/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2749884
The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I (I). The structures of rings A and B and substituents R a, R b and R c are described in the specification. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis, treatment and inhibition of cannabinoid receptor- associated diseases and conditions, such as pain, inflammation and pruritis.
La présente invention concerne des hétérocycles pyrazolo substitués ayant la structure générale de formule I (I). Les structures des cycles A et B et les substituants Ra, Rb et Rc sont décrits dans la description. Elle concerne également des sels, sels d'acides, hydrates, solvats et stéréo-isomères pharmaceutiquement acceptables des composés de formule I. Les composés sont utiles comme modulateurs de récepteurs cannabinoïdes et pour la prophylaxie, le traitement et l'inhibition de maladies et d'états associés aux récepteurs cannabinoïdes, comme la douleur, l'inflammation et le prurit.
Cara Therapeutics Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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