C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/00 (2006.01) A61K 31/4162 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2545781
The present invention relates to 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.
La présente invention concerne des 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones qui inhibent la libération extracellulaire de cytokines inflammatoires, cytokines qui sont responsables d'un ou de plusieurs états pathologiques chez les humains ou chez les mammifères supérieurs. La présente invention concerne également des compositions comprenant lesdites 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones ainsi que des méthodes de prévention, de diminution ou autrement dit de régulation d'enzymes qui s'avèrent être les composants actifs responsables des états pathologiques susdécrits.
Brugel Todd Andrew
Clark Michael Philip
Golebiowski Adam
Laughlin Steven Karl
Sabat Mark
The Procter & Gamble Company
Torys Llp
LandOfFree
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