Bicyclic pyrimidine derivatives as calcium channel blockers

Details Bicyclic pyrimidine derivatives as calcium channel blockers Bicyclic pyrimidine derivatives as calcium channel blockers

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2685753

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).

La présente invention a pour objet des procédés et des composés efficaces dans l'amélioration d'affections caractérisées par une activité indésirée des canaux calciques, particulièrement une activité indésirée des canaux calciques de type T. De manière spécifique, l'invention concerne une série de composés contenant des dérivés de thiénopyrimidine ou d'oxoquinazoline de formule générale (1) ou de formule (2) où X représente un lieur et Y représente un radical aromatique ou N(R5)(R6).

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