Bicyclic pyrrole compound

Details Bicyclic pyrrole compound Bicyclic pyrrole compound

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 13/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2718252

Disclosed is a compound composed of an easily-handleable crystal form and having storage stability that is practical enough to be used as an active ingredient of a pharmaceutical product. Specifically disclosed is 6-[(3R)-3-aminopiperidin-1-yl]-5-(2-chloro-5-fluorobenzyl)-1,3-dimethyl-1H- pyrrolo[3,2-d]pyrimidine-2, 4(3H,5H)-dione monohydrochloride hemihydrate.

L'invention porte sur un composé se composant d'une forme cristalline facilement manipulable et ayant une stabilité au stockage qui est suffisamment pratique pour l'utiliser comme ingrédient actif d'un produit pharmaceutique. De façon spécifique, l'invention porte sur le monochlorhydrate de 6-[(3R)-3-aminopipéridin-1-yl]-5-(2-chloro-5-fluorobenzyl)-1,3-diméthyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione hémihydraté.

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