Bicyclic quinone compounds, their production and use

Details Bicyclic quinone compounds, their production and use Bicyclic quinone compounds, their production and use

C - Chemistry, Metallurgy

07

C

C07C 50/32 (2006.01) A61K 31/12 (2006.01) C07C 45/51 (2006.01) C07C 47/277 (2006.01) C07C 47/575 (2006.01) C07C 49/755 (2006.01) C07C 62/38 (2006.01) C07C 65/40 (2006.01) C07C 66/00 (2006.01) C07C 69/007 (2006.01) C07C 69/738 (2006.01) C07C 69/74 (2006.01) C07C 69/757 (2006.01) C07C 69/92 (2006.01) C07C 217/58 (2006.01) C07C 225/14 (2006.01) C07C 233/25 (2006.01) C07C 233/31 (2006.01) C07C 235/46 (2006.01) C07C 235/82 (2006.01) C07C 255/56 (2006.01) C07C 271/12 (2006.01) C07D 209/48 (2006.01) C07D 211/32 (2

Patent

CA 2276171

A compound of formula (I), wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the principal chain is 1 to 15; Y represents an acyl, or a hydroxy, an amino or an aromatic group, each of which may be substituted; and ring A represents a 5- to 8-membered ring which may be further substituted apart from -X-Y, or a salt thereof is useful as a pharmaceutical composition for preventing or treating disease related to mitochondrial dysfunction.

L'invention concerne un composé de la formule (I) ou un sel de celui-ci. Dans cette formule, R?1¿ et R?2¿ représentent chacun alkyle inférieur, ou bien R?1¿ et R?2¿ peuvent être liés pour former un noyau, X représente un bras d'écartement dont le nombre d'atomes constituant la chaîne principale est compris entre 1 et 15, Y représente acyle, hydroxy, amino ou un groupe aromatique, pouvant chacun être substitué, et A représente un noyau possédant 5 à 8 chaînons, pouvant être ultérieurement substitué, sauf pour -X-Y-. Ce composé est utile en tant que composition pharmaceutique destinée à prévenir ou traiter une maladie associée à un dysfonctionnement mitochondrial.

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