Bicyclic signal transduction inhibitors, compositions...

C - Chemistry – Metallurgy – 07 – C

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C07C 237/20 (2006.01) A61K 31/165 (2006.01) A61P 9/00 (2006.01) A61P 19/10 (2006.01) A61P 37/00 (2006.01) C07C 237/22 (2006.01) C07C 237/48 (2006.01) C07D 313/08 (2006.01) C07D 327/02 (2006.01) C07F 9/12 (2006.01) C07F 9/38 (2006.01) C07F 9/40 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2345459

This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula (I) as defined herein.

L'invention concerne des composés permettant l'inhibition de la transduction de signaux intracellulaires, en particulier par l'intermédiaire d'une ou de plusieurs interactions moléculaires faisant intervenir une protéine contenant de la phosphotyrosine. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes prophylactiques et thérapeutiques reposant sur l'administration pharmaceutique et vétérinaire desdits composés. Ces composés présentent la structure de la formule (I), telle que définie dans le descriptif.

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