Bicyclic-substituted 4-amino-pyridopyrimidine derivatives

Details Bicyclic-substituted 4-amino-pyridopyrimidine derivatives Bicyclic-substituted 4-amino-pyridopyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2381513

The invention relates to 6- or 7-bicyclic- substituted 4-amino-substituted pyridopyrimidines of the formula: (see formula 1) (wherein R1 is H or alkyl and R3 is -(CR1R2)m-R4 or -NR1R3 taken together form an indole (or indoline) ring; one of X and Y is N and the other is CR9; R2 is H of alkyl; m is 0 to 6; R4 is aryl or heteroaryl; and R9 is a fused or bridged bicyclic or spirobicyclic ring) and to pharmaceutically acceptable salts, prodrugs and hydrates thereof useful in treating hyperproliferative disorders in a mammal. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating hyperproliferative disorders abnormal cell growth in a mammal by administering the compounds.

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