C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 215/12 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2566896
Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Des composés de formule (I) où R¿1? ou R¿2? est un cycle aromatique ou non aromatique directement lié ou lié par un liant, tel que représenté par L¿2 ?et L¿3?, à un noyau hétéroaromatique, et X, X', Y, Y', Z, Z', R¿1?, R¿2?, R¿3?, R¿3a?, R¿3b?, R¿4?, R¿5?, L, L¿2?, et L¿3? sont tels que définis ici, sont utiles pour le traitement de maladies ou de troubles prévenus ou améliorés par des ligands du récepteur de l~histamine-3. Sont également décrites des compositions pharmaceutiques comprenant des ligands du récepteur de l~histamine-3, des procédés pour l~utilisation de tels composés et compositions, et un procédé pour préparer des composés dans le champ d~application de la formule (I).
Altenbach Robert J.
Black Lawrence A.
Chang Sou-Jen
Cowart Marlon D.
Curtis Michael P.
Abbott Laboratories
Torys Llp
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