Bicyclic tetrahydro pyrazolopyridines and their use as...

Details Bicyclic tetrahydro pyrazolopyridines and their use as... Bicyclic tetrahydro pyrazolopyridines and their use as...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2201728

Compounds of formula (I) wherein R1, R2, R3 and X are as defined. The compounds of formula (I) and the pharmaceutically acceptable salts thereof are useful in inhibiting phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) and in the treatment of asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases, AIDS, septic shock and other diseases involving the production of TNF.

L'invention concerne des composés de formule (I) où R?1¿, R?2¿, R?3¿ et X sont tels que définis. Les composés de cette formule (I) ainsi que leurs sels acceptables du point de vue pharmaceutique s'avèrent efficaces comme inhibiteurs de la phosphodiestérase (PDE) de type IV et de la production du facteur de nécrose des tumeurs (TNF) ainsi que dans le traitement de l'asthme, de l'arthrite, de la bronchite, des maladies chroniques obstructives des voies respiratoires, du psoriasis, des rhinites allergiques, des dermatites et autres maladies inflammatoires, du syndrome d'immuno-déficience acquise, du choc septique et d'autres affections donnant lieu à une production de TNF.

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