Bicyclo[2.2.1]heptanes and related compounds

Details Bicyclo[2.2.1]heptanes and related compounds Bicyclo[2.2.1]heptanes and related compounds

C - Chemistry, Metallurgy

07

C

C07C 229/50 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2321639

The present invention relates to compounds of formula (I), wherein n is 0-6; X is CH2, CH2CH2 or oxygen; Z is CHR2 or NR2; R and R2 are selected independently from hydrogen, (C1-C6)alkyl, aryl and heteroaryl, wherein said aryl is selected from phenyl and naphthyl and said heteroaryl is selected from 5 and 6 membered aromatic heterocyclic rings that contain from one to four heteroatoms selected independently, from nitrogen, oxygen and sulfur, and wherein said aryl and heteroaryl moieties can optionally be substituted with one or more substituents that are selected, independently, from halo, -S(C1-C6)alkyl, - S(O)(C1-C6)alkyl, -S(O)2(C1-C6)alkyl, (C1-C6)alkyl optionally substituted with from one to seven fluorine atoms, (C1-C6)alkoxy optionally substituted with from one to seven fluorine atoms, amine nitro, cyano, carboxy, -CO2(C1-C6)alkyl, (C1-C6)alkylamino, di-[(C1- C6)alkyl]amino phenoxy, anilino and phenylthio; pharmaceutics compositions containing such compounds (I) and the use of such compounds (I) to treat neurological and psychiatric disorders.

Cette invention concerne des composés de formule (I), des compositions pharmaceutiques contenant les composés (I) et l'utilisation de ces composés (I) pour traiter des troubles neurologiques et psychiques. Dans la formule (I), n est compris entre 0 et 6; X représente CH2, CH2CH2 ou oxygène; Z représente CHR<2> ou NR<2>; R<1> et R<2> sont sélectionnés indépendamment entre hydrogène, alkyle (C1-C6), aryle et hétéroaryle, ledit aryle étant sélectionné entre phényle et naphtyle et ledit hétéroaryle étant sélectionné parmi des anneaux hétérocycliques aromatiques à 5 ou 6 éléments qui contiennent de un à quatre hétéroatomes sélectionnés indépendamment entre azote, oxygène et soufre, les fractions aryle et hétéroaryle pouvant être facultativement substituées par un ou plusieurs substituants qui sont sélectionnés indépendamment entre halo, -S alkyle (C1-C6), -S (O) alkyle (C1-C6), -S (O)2 alkyle (C1-C6), alkyle (C1-C6) facultativement substitué par un à sept atomes de fluor, alcoxy (C1-C6) facultativement substitué par un à sept atomes de fluor, amino, nitro, cyano, carboxy, -CO2 alkyle (C1-C6), alkylamino (C1-C6), di-[alkyle (C1-C6)]amino phénoxy, anilino et phénylthio.

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