Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/10 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61P 31/04 (2006.01) C07D 263/20 (2006.01) C07D 263/24 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2443410

Oxazolidinones having a bicyclic[3.1.0]hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, Streptococci and enterococci, Bacteroides spp., Clostridia spp.species, as well as acid-fast organisms such as MYCOBACTERIUM TUBERCULOSISand other mycobacterial species. The compounds are represented by structural formula I: its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof, and wherein the variables R1, R2, R3, R4a, A, Ar, HAr, n, r, and s are as defined herein.

La présente invention concerne des oxazolidinones comprenant une fraction contenant de l'hexane bicyclique [3.1.0], qui sont efficaces contre les pathogènes aérobie et anaérobie tels que des staphylocoques, des streptocoques et des entérocoques multirésistants, des bactéroïdes spp, des espèces clostridia spp ainsi que des organismes acido-résistants tels que le bacille de la tuberculose Mycobacterium tuberculosis et d'autres espèces de mycobactéries. Les composés sont représentés par la formule (I) dans laquelle les variables R¿1?, R¿2?, R¿3?, R¿4?, R¿4a?, A, Ar, Har, r et s sont telles que définies dans le descriptif. La présente invention concerne lesdits composés ainsi que leur forme énantiomère, diastéréomère ou bien leurs sels ou leurs esters pharmaceutiquement acceptables. Formule (I)

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