A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4025 (2006.01) A61K 31/397 (2006.01) A61K 31/4184 (2006.01) A61K 31/4523 (2006.01) A61K 31/517 (2006.01) A61P 29/02 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2534833
The invention relates to a group of hydronopol substituted benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel benzimidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.
L'invention porte: sur un groupe de dérivés de la benzimidazolone et de la quinazolinone à substitution hydronopol, agonistes du récepteur ORL1 (nociceptine); sur l'élaboration de ces composés; sur des préparations pharmaceutiques les contenant comme principe actif; et sur l'utilisation de ces préparations pour le traitement de troubles impliquant les récepteurs ORL1. L'invention porte en outre sur des composés de formule générale (1) dans laquelle les différents symboles ont la signification donnée dans la description.
David Samuel
Den Hartog Jacobus A. J.
Jasserand Daniel
Tuinstra Tinka
Van Scharrenburg Gustaaf J. M.
Fetherstonhaugh & Co.
Solvay Pharmaceuticals B.v.
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