C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 405/00 (2006.01) A61K 31/557 (2006.01) A61K 31/715 (2006.01) C07D 213/54 (2006.01) C07D 257/04 (2006.01) C07D 263/14 (2006.01) C07D 307/54 (2006.01) C07D 319/06 (2006.01) C07D 333/24 (2006.01) C07D 493/08 (2006.01) C08B 37/16 (2006.01)
Patent
CA 2058922
Abstract The invention relates to bicyclo[3.3.0]octane derivatives of formula I, Image (I), as well as their enantiomers, in which at most one double bond lies between the carbon atoms of centers a-b or b-c or b-d, R1 can be Image , Image , Image , Image , COOR5, and R5 can mean hydrogen or C1-C10 alkyl, C3-C10 cycloalkl, C7-C16 aralkyl, optionally substituted by halogen, phenyl, C1-C4 alkoxy or di-(C1-C4)-alkylamino, phenacyl or C6-C12 aryl substituted by Y or a 5- or 6-membered heterocyclic radical with at least one N, O or S atom, or -CONHR7 with R7 meaning hydrogen, C1-C10 alkanoyl or C1-C10alkanesulfonyl, X means a CH2 group or an O or S atom, n means 0-2, R4 means a hydrogen atom, a free or functionally modified hydroxy group, and the OH group can be in .alpha.- or .beta.-position, Z means Image , Image , Image , Image , Image p means 0 or 1, V means an O or S atom, W means C1-C10 alkyl, C3-C10 cycloalkyl, Image , Image , Image , Image , Image , Image , Image , Image , Image substituted by Y, Y1, Y2 and Y3 are the same or different and mean Y, Y means hydrogen, halogen, N3, CF3, OR6, NO2, COOR6 or C1-C10 alkyl, R6 can be hydrogen, C1-C10 alkyl, C6-C12 aryl or C7-16 aralkyl optionally substituted by halogen and, if R5 means hydrogen, their salts with physiologically compatible bases, as well as the .alpha.-, .beta.- or .gamma. -cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and their pharmaceutical use.
Klar Ulrich
Rehwinkel Hartmut
Thierauch Karl-Heinz
Verhallen Peter
Vorbrueggen Helmut
Marks & Clerk
Schering Aktiengesellschaft
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