Bicyclo derivative

Details Bicyclo derivative Bicyclo derivative

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 7/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/08 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01) A61P 37/04 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2557275

Disclosed is a novel bicyclo derivative having excellent DPP-IV inhibitory activity which is represented by the general formula (1) below or a pharmacologically acceptable salt thereof. (Specific examples thereof include (2S,4S)-1-[[N-(4-methylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4- fluoropyrrolidine-2-carbonitrile.)

Il est divulgué un nouveau dérivé bicyclo ayant une activité inhibitrice DPP-IV qui est représentée par la formule (1) ci-après ou un sel pharmaceutiquement acceptable. (des exemples spécifiques (2S,4S)-1-[[N-(4-methylbicyclo[2.2.2]oct-1-yl)amino]acétyl]-4-fluoropyrrolidine-2-carbonitrile.) (1)

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