Bicyclo-pyrazole derivatives active as kinase inhibitors,...

Details Bicyclo-pyrazole derivatives active as kinase inhibitors,... Bicyclo-pyrazole derivatives active as kinase inhibitors,...

A - Human Necessities

61

K

A61K 31/4162 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2518395

Compounds which are pyrrolo-pyrazole derivatives and pharmaceutically acceptable salts thereof, together with the process for their preparation and pharmaceutical compositions thereof are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

Cette invention, qui concerne certains composés, des dérivés de pyrrolo-pyrazol et leurs sels acceptable du point de vue pharmaceutique, a également trait au procédé permettant de les préparer ainsi qu'à des compositions pharmaceutiques les contenant. Ces composés ou ces compositions se révèlent des plus utiles dans le traitement d'états pathologiques causés par une modification de l'activité de la protéine kinase ou associés à celle-ci, notamment le cancer, des troubles de la prolifération cellulaire, la maladie d'Alzheimer, des infections virales, des maladies auto-immunes et des troubles neurodégénératifs.

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