C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2493625
The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrazole- tetrahydro pyridine derivative. The invention also provides specific pyrazole- tetrahydro pyridines, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
La présente invention porte sur un procédé de traitement de maladies provoquées et/ou associées à une modification d'activité de la protéine kinase. Ce procédé consiste à administrer à un mammifère nécessitant un traitement une quantité efficace d'un dérivé de pyrazole-tétrahydro pyridine. L'invention porte également sur des pyrazole-tétrahydro pyridines spécifiques, sur une bibliothèque comprenant au moins deux de ces dérivés, sur leur procédé de préparation et sur les compositions pharmaceutiques les contenant, ces dérivés étant utiles dans le traitement de maladies provoquées et/ou associées à une modification d'activité de la protéine kinase telles que le cancer, les maladies à prolifération cellulaire, les infections virales, les maladies auto-immunes et les troubles neurodégénératifs.
Abrate Francesca
Fancelli Daniele
Varasi Mario
Villa Manuela
Vulpetti Anna
Pharmacia & Italia S.p.a.
Smart & Biggar
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