C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/415 (2006.01) A61K 31/55 (2006.01) C40B 40/04 (2006.01)
Patent
CA 2493637
The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrrolo- pyrazole or pyrazolo-azepine. The invention also provides specific pyrrolo- pyrazoles and pyrazolo-azepines, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
La présente invention concerne une méthode de traitement de maladies causées par et/ou associées à une activité de protéine kinase altérée, consistant à administrer à un mammifère en ayant besoin une quantité efficace de pyrrolo-pyrazole ou de pyrazolo-azépine. L'invention concerne également des pyrrolo-pyrazoles et des pyrazolo-azépines spécifiques, des intermédiaires, une bibliothèque en contenant au moins deux, un procédé de préparation, et les compositions pharmaceutiques les contenant, utilisés dans le traitement de maladies causées par et/ou associées à une activité de protéine kinase altérée telles que le cancer, les troubles prolifératifs cellulaires, les infections virales, les maladies auto-immunes et les troubles neurodégénératifs.
Abrate Francesca
Fancelli Daniele
Varasi Mario
Villa Manuela
Vulpetti Anna
Pharmacia & Italia S.p.a.
Smart & Biggar
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