Bicyclo-substituted phenylacetonitrile derivatives

Details Bicyclo-substituted phenylacetonitrile derivatives Bicyclo-substituted phenylacetonitrile derivatives

C - Chemistry, Metallurgy

07

C

167/251, 260/558

C07C 255/32 (2006.01) A61K 31/135 (2006.01) A61K 31/275 (2006.01) C07C 255/33 (2006.01) C07C 255/42 (2006.01) C07C 255/43 (2006.01)

Patent

CA 1276178

ABSTRACT OF THE INVENTION The invention relates to compounds of the formula: Image and the pharmaceutically acceptable salts and hydrates thereof wherein R1 and R2 are the same or different and each is selected from hydrogen,halo, C1-C4 alkyl, C1-C4 alkoxy or tri- fluoromethyl; R3 is selected from straight or branched chain (a) alkyl of from about 1 to 15 carbon atoms or (b) alkenyl of from about 2 to 15 carbon atoms; R4 is selected from hydrogen or C1-C4 alkyl; R5 is a bicyclic group selected from Image or Image wherein R6 and R7 are the same as defined above for R1 and R2; and n is an integer from 2 to 4, inclusive; which are useful as cardiovascular agents.

520675

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