Bicyclo-substituted pyrazolon azo derivatives, preparation...

Details Bicyclo-substituted pyrazolon azo derivatives, preparation... Bicyclo-substituted pyrazolon azo derivatives, preparation...

C - Chemistry, Metallurgy

07

D

C07D 231/20 (2006.01) A61K 31/343 (2006.01) A61K 31/352 (2006.01) A61K 31/4152 (2006.01) A61K 31/655 (2006.01) A61P 7/00 (2006.01) C07D 307/79 (2006.01) C07D 311/04 (2006.01)

Patent

CA 2711535

The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description. (see formula I)

La présente invention concerne des dérivés azoïques de pyrazolone à substitution bicyclo répondant à la formule (I) ou des sels, hydrates ou solvates pharmaceutiquement acceptables de ces dérivés, leurs méthodes de préparation, des compositions pharmaceutiques contenant lesdits dérivés ou sels, hydrates ou solvates pharmaceutiquement acceptables et leur utilisation en tant qu'agent thérapeutique, en particulier en tant que mimétiques de la thrombopoïétine (TPO) et leur utilisation en tant qu'agonistes du récepteur de la thrombopoïétine. Les définitions des substituants représentés par la formule (I) sont celles de la description.

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