Bicycloamide derivative

Details Bicycloamide derivative Bicycloamide derivative

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/4025 (2006.01) A61K 31/4192 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 7/10 (2006.01) A61P 9/12 (2006.01) A61P 13/08 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/18 (2006.

Patent

CA 2554378

Novel bicyclic amide derivatives having excellent DPP-IV inhibiting activity or pharmacologically acceptable salts thereof. Namely, novel bicyclic amide derivatives represented by the general formula (1) or pharmacologically acceptable salts thereof (for example, (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2] oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile).

Nouveaux dérivés d'amides bicycliques ayant une excellente activité d'inhibition de la DPP-IV ou sels acceptables du point de vue pharmacologique de ceux-ci. A savoir, nouveaux dérivés d'amides bicycliques représentés par la formule générale (1) ou sels acceptables du point de vue pharmacologique de ceux-ci (par exemple le (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acétyl]-4-fluoropyrrolidine-2-carbonitrile). (1)

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