C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01) C07F 5/00 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07K 1/13 (2006.01) C07K 14/00 (2006.01) C08B 37/02 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)
Patent
CA 2103553
2103553 9312112 PCTABS00022 Complexes of bicyclopolyazamacrocyclocarboxylic acid compounds with a metal ion, e.g. 153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115mIn ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes. Processes to prepare the complex and conjugate are discussed.
Kiefer Garry E.
Simon Jaime
Smart & Biggar
The Dow Chemical Company
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