Bicyclopolyazamacrocyclocarboxylic acid complexes, their...

Details Bicyclopolyazamacrocyclocarboxylic acid complexes, their... Bicyclopolyazamacrocyclocarboxylic acid complexes, their...

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 49/08 (2006.01) C07D 487/08 (2006.01) C07F 5/00 (2006.01) C07F 13/00 (2006.01) C07F 15/02 (2006.01) C07K 2/00 (2006.01) C07K 16/28 (2006.01) C08B 37/02 (2006.01)

Patent

CA 2139738

2139738 9426313 PCTABS00034 Complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn or Fe ions are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes. Processes for preparing both the complex and conjugate are disclosed.

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