C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 275/06 (2006.01) A61K 31/428 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 411/10 (2006.01) C07D 413/10 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2687415
This invention pertains generally to the field of therapeutic compounds, and more particularly, to certain bicyclosulfonyl acid (BCSA) compounds which act as inhibitors of Tumour Necrosis Factor-.alpha. Converting Enzyme (TACE). The compounds are useful in the treatment of conditions mediated by TNF-.alpha., such as rheumatoid arthritis; inflammation; psoriasis; septic shock; graft rejection; cachexia; anorexia; congestive heart failure; post ischaemic reperfusion injury; inflammatory disease of the central nervous system; inflammatory bowel disease; insulin resistance; HIV infection; cancer; chronic obstructive pulmonary disease (COPD); and asthma. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in the inhibition of TACE, and in the treatment of conditions that are ameliorated by the inhibition of TACE.
Cette invention appartient d'une manière générale au domaine des composés thérapeutiques et plus particulièrement, à certain composés de l'acide bicyclosulfonylique (BCSA) qui agissent comme inhibiteurs de l'enzyme de conversion du facteur .alpha. de nécrose tumorale (TACE). Ces composés s'avèrent utiles dans le traitement de états médiés par le TNF-.alpha., tels que la polyarthrite chronique évolutive; l'inflammation; le psoriasis; le choc septique; le rejet de greffe; la cachexie; l'anorexie; l'insuffisance cardiaque congestive; les maladies inflammatoires du SNC; l'affection abdominale inflammatoire; la résistance à l'insuline; l'infection par le VIH; le cancer; la bronchopneumopathie chronique obstructive et l'asthme. L'invention porte également sur des compositions pharmaceutiques comprenant de tels composés et sur l'utilisation de tels composés et compositions, tant in vitro qu'in vivo, pour l'inhibition du TACE et pour le traitement d'états améliorées par l'inhibition du TACE.
Finn Paul
Jirgensons Aigars
Kalvinsh Ivars
Khan Nagma
Leitis Gundars
Inhibox Ltd.
Kirby Eades Gale Baker
LandOfFree
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