Bidentate metalloprotease inhibitors

Details Bidentate metalloprotease inhibitors Bidentate metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/48 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 211/96 (2006.01) C07D 223/02 (2006.01) C07D 401/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 491/113 (2006.01) C07D 495/10 (2006.01) C07F 9/572 (2006.01) C07F 9/59 (2006.01)

Patent

CA 2263914

The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester, acyloxyamide, or imide thereof. Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

La présente invention concerne des composés convenant comme inhibiteurs de métalloprotéases et qui sont efficaces dans le traitement d'états caractérisés par une activité excessive de ces enzymes. L'invention concerne en l'occurrence, non seulement un composé dont la structure est représentée par la formule générale (I) telle qu'elle est revendiquée, mais aussi l'un de ses isomères optiques, l'un de ses diastéréomères ou énantiomères, l'un de ses sels pharmaceutiquement admis, ou encore l'un de ses alcoxylamides biohydrolysables, l'un de ses esters, l'un de ses acyloxyamides, ou l'un de ses imides. L'invention concerne également des composés, des compositions pharmaceutiques et des thérapies dirigées contre des affections caractérisées par une activité de métalloprotéase, lesquelles thérapies impliquent l'utilisation de ces composés ou de compositions pharmaceutiques contenant ces composés.

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