Bifunctional chelating agent for actinium

Details Bifunctional chelating agent for actinium Bifunctional chelating agent for actinium

C - Chemistry, Metallurgy

07

D

C07D 259/00 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07F 9/6524 (2006.01)

Patent

CA 2458267

The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents -X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z, NHCO-W-COCNHS, -NH-Q, -NHCS-Q, -NHCOCH2-Q, or NHCO(CH2)m- Q where Q is a hapten chosen from the group consisting of steroids, enzymes, proteins, monoclonal antibodies, chimeric antibodies, or fragments thereof or any activated linker ready for coupling reaction, W is -(CH2)m- m is an integer from 1 to 10 Z is chloride, bromide or iodine.

L'invention concerne un ligand de formule (I), dans laquelle n est un nombre entier compris entre 1 et 5 ; Y représente -CO¿2?H ou -PO¿3?H¿2 ?; T représente -X ou phényl-X, X représentant NO¿2?, -NH¿2?, -NCS, -NHCOCH¿2?-Z, -NHCO-W-COCNHS, -NH-Q, -NHCS-Q, -NHCOCH¿2?-Q, ou NHCO(CH¿2?)¿m?-Q, Q étant un haptène choisi dans le groupe constitué de stéroïdes, d'enzymes, de protéines, d'anticorps monoclonaux, d'anticorps chimériques, ou de fragments de ces derniers ou de tout autre lieur actif prêt pour une réaction de couplage ; W représente (CH¿2?)¿m?- ; m est un nombre entier compris entre 1 et 10 ; Z représente chlorure, bromure ou iode.

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