Bifunctional chelating agents

Details Bifunctional chelating agents Bifunctional chelating agents

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/06 (2006.01) A61K 51/04 (2006.01)

Patent

CA 1281500

ABSTRACT OF THE DISCLOSURE Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a ratiodiagnostic agent for use in in vivo imaging and a method for producing this chelating agent. The novel com- pounds have the formula: Image I wherein R is hydrogen or lower alkyl, R1 and R2 are individually hydrogen or lower alkyl or taken together form oxo; R3 is an amino protecting group where R1 and R2 are individually hydrogen or lower alkyl; R3 is hydrogen when R1 and R2 taken together form oxo; R4 is hydrogen or lower alkyl; R5 is hydrogen or a thiol protecting group; x and y are integers from 0 to 2

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