Bifunctional coupling agents and radionuclide labeled...

Details Bifunctional coupling agents and radionuclide labeled... Bifunctional coupling agents and radionuclide labeled...

C - Chemistry, Metallurgy

07

C

167/14, 260/471,

C07C 327/30 (2006.01) A61K 51/10 (2006.01) C07C 327/32 (2006.01) C07D 207/452 (2006.01) C07K 1/13 (2006.01)

Patent

CA 1340665

A bifunctional coupling agent for joining a sulfhydryl-containing protein or peptide and a metallic radionuclide comprising a sulfhydryl selective electrophile, a chelator containing at least one protected thiol and a organic linking radical which serves to join said electrophile and said chelator is disclosed. A radiodiagnostic precursor comprising an antibody or antibody fragment and the specified bifunctional coupling agent bound to a sulfhydryl group on the antibody or antibody fragment is also disclosed.

602923

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