Bifunctional fusion proteins of the alpha-melanocyte...

C - Chemistry – Metallurgy – 07 – K

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C07K 19/00 (2006.01) A61K 38/22 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01) C07K 14/575 (2006.01) C07K 14/58 (2006.01) C07K 14/685 (2006.01)

Patent

CA 2691898

A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).

L'invention concerne une hormone bifonctionnelle présentant une activité alpha-MSH et une activité peptidique natriurétique. L'hormone bifonctionnelle comprend par exemple un premier domaine présentant une activité hormonale associée à l'alpha-MSH, lié de manière covalente à un second domaine présentant une activité hormonale associée au peptide natriurétique. L'hormone bifonctionnelle de la présente invention est par exemple utile pour la prévention et/ou le traitement de maladies ou de troubles d'ordre rénal, tels que l'insuffisance rénale aiguë (IRA) ou la lésion rénale aiguë (LRA).

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