C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/24 (2006.01) A61K 38/47 (2006.01) C07K 16/00 (2006.01) C12N 15/56 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2435037
The present invention relates to novel Glucocerebrosidase bifunctional fusion proteins consisting essentially of an Immunoglobulin (Ig) molecule and a protein having the biological activity of Glucocerebrosidase, for enzyme replacement therapy and/or augmentation of glycolipid metabolism by the administration of bifunctional fusion proteins using a therapy based on the treatment of glycolipid storage disorders such as Gaucher's, Fabry's and Tay- Sachs diseases.
L'invention porte sur de nouvelles protéines de fusion bifonctionnelles de glucocerebrosidase contenant principalement une molécule d'immunoglobuline (Ig) et une protéine possédant l'activité biologique de la glucocerebrosidase. Ces protéines sont utilisées dans la thérapie de substitution d'enzyme et/ou l'augmentation du métabolisme glycolipide par l'administration de protéines de fusion bifonctionnelles au moyen d'une thérapie fondée sur le traitement des troubles de stockage glycolipide, tels que la maladie de Gaucher, de Fabry et de Tay-Sachs.
Gillies Stephen
Schumacher Silke
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschrankter Haftung
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