Bifunctional molecules and therapies based thereon

Details Bifunctional molecules and therapies based thereon Bifunctional molecules and therapies based thereon

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C12N 9/90 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2330611

The disclosed invention describes bifunctional conjugates of the form Z-L-X, where Z is a ligand that binds to a specific protein, X is a drug moiety (e.g. antimicrobial agent, etc.), and L is an optional linker. The design of the conjugate is such that upon entering a cell, the ligand Z can bind to its receptor protein (if such a receptor protein is present) and the drug's effectiveness is thereby enhanced or inhibited, depending on the nature of Z's receptor.

L'invention concerne des conjugués de forme Z-L-X, Z représentant un ligand qui se fixe à une protéine spécifique, X représentant un fragment médicamenteux (ex. agent antimicrobien, etc) et L un segment de liaison éventuel. Le conjugué est conçu, de sorte que, lorsqu'il entre dans une cellule, le ligand Z puisse se lier à sa protéine réceptrice (si elle est présente), l'efficacité du médicament étant ainsi accrue ou inhibée, selon la nature du récepteur de Z.

Affiliated with

Also associated with

Rating

Bifunctional molecules and therapies based thereon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bifunctional molecules and therapies based thereon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bifunctional molecules and therapies based thereon will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1903427