Bifunctional molecules and vectors complexed therewith for...

Details Bifunctional molecules and vectors complexed therewith for... Bifunctional molecules and vectors complexed therewith for...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/485 (2006.01) C07K 14/525 (2006.01) C07K 14/65 (2006.01) C07K 16/08 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2414272

Methods and products for targeting delivery vectors, such as adenoviral gene delivery particles, to selected cell types are provided. The methods rely on targeting by a bifunctional molecule that specifically complexes with a protein on the vector particle surface and with targeted cell surface proteins. The targeted cell surface proteins are any that activate the phosphatidylinositol-3-OH kinases. The bifunctional molecules, compositions, kits, and methods of preparation and use of the vector/bifunctional molecules for gene therapy are provided.

L'invention concerne des procédés et produits destinés à des vecteurs d'apport et de ciblage, tels que des particules d'apport de gènes adénoviraux à des types choisis de cellules. Ces procédés reposent sur le ciblage par une molécule bifonctionnelle, laquelle se complexe avec une protéine sur la surface particulaire du vecteur et avec des protéines de surface de cellules ciblées. Les protéines de surface de cellules ciblées peuvent être toute protéine activant les phosphatidylinositol-3-OH kinases. L'invention concerne encore des molécules bifonctionnelles, des compositions et trousses, ainsi que des procédés de préparation et d'utilisation de ces molécules bifonctionnelles/vecteurs, destinés à la thérapie génique.

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